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This volume was prepared especially keeping the applied statisticians in mind, emphasizing applications-oriented methods and techniques, including references to appropriate software when relevant. The contributors are internationally renowned experts in their respective areas. This volume addresses emerging statistical challenges in epidemiological, biomedical, and pharmaceutical research. It features: methods for assessing Biomarkers, analysis of competing risks; clinical trials including sequential and group sequential, crossover designs, cluster randomized, and adaptive designs; and, structural equations modelling and longitudinal data analysis.